What is Spravato (Esketamine)?
Spravato is a prescription nasal spray used for adults with treatment-resistant depression. Unlike traditional antidepressants (like SSRIs) that can take weeks or months to kick in, Spravato is known for its ability to work much faster—sometimes within hours or days.
How It Works: The "Brain Rewiring" Effect
Most older antidepressants target chemicals like serotonin or dopamine. Spravato targets glutamate, the most abundant chemical messenger in your brain.
The Problem: In people with chronic depression, the "synapses" (the bridges that allow brain cells to talk to each other) can shrink or break down over time, almost like a garden that hasn't been watered.
The Spravato Solution: It triggers a process called synaptogenesis. Think of it as "fertilizer" for the brain; it helps those connections regrow and strengthens the pathways that regulate mood.
The Treatment Experience
Because Spravato can cause temporary "dissociative" effects (feeling floaty or detached) and a brief spike in blood pressure, you cannot take it at home.
Medical Supervision: You administer the spray yourself at a certified doctor's office or clinic.
The Observation Period: After taking the dose, you’ll stay in a comfortable chair for about two hours while medical staff monitor your vitals and ensure you’re feeling okay.
The "No Drive" Rule: You’ll need a ride home and should rest until the next day, as the medicine can make you feel drowsy or "loopy" for several hours.
Why is this Different?
The biggest takeaway is that Spravato isn't just "more medicine"—it’s a different mechanism.
By focusing on the structural health of your brain's communication network rather than just balancing mood chemicals, it offers a new path for people who haven't found relief through traditional therapy.
Ready for the next step?
If you are ready to take the next step to schedule, click the button at the top of the screen and schedule a free 15 minute call. We look forward to talking with you!
More Than Spravato®
Unlike clinics that simply administer treatment, Journey to Wellness provides comprehensive psychiatric care before, during, and after every Spravato® treatment.
Our approach includes:
✔ Comprehensive psychiatric evaluation
✔ Medication management
✔ Therapy when appropriate
✔ Integrative psychiatry
✔ Personalized treatment planning
✔ Long-term follow-up
✔ Compassionate, patient-centered care
Benefits of Spravato®
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May begin improving symptoms faster than many traditional antidepressants for eligible patients.
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Encourages the formation of new neural connections that may improve mood and emotional flexibility
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Designed for adults with treatment-resistant depression who haven't found relief with standard medications.
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Many patients experience increased motivation, better energy, and greater engagement in everyday life.
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Every treatment is provided under medical supervision in a comfortable, supportive environment.
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Your treatment plan is customized and adjusted based on your symptoms, progress, and goals.
Am I a Good Candidate for Spravato®?
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If you've taken two or more antidepressants without achieving adequate relief, Spravato® may be an effective next step in your treatment journey.
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Spravato® is FDA-approved for adults with treatment-resistant depression who continue to experience symptoms despite trying standard antidepressant medications.
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Because Spravato® works differently than traditional antidepressants, it may benefit individuals who haven't responded to conventional treatments.
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Spravato® is administered in our office under medical supervision. Each visit includes treatment followed by at least two hours of monitoring, and you'll need someone to drive you home afterward.
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The best outcomes often come from combining Spravato® with ongoing psychiatric care, therapy, healthy lifestyle habits, and a personalized treatment plan.
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If depression continues to interfere with your relationships, work, or quality of life, Spravato® may provide another evidence-based treatment option when other approaches haven't been enough.
What to Expect on Your Spravato® Journey
Initial Consultation
We'll complete a comprehensive psychiatric evaluation, review your medical history, previous treatments, current medications, and determine whether Spravato® is an appropriate option for you.
Your Treatment Session
Spravato® is self-administered as a nasal spray under medical supervision. You'll relax in a comfortable treatment room while our team monitors your blood pressure, symptoms, and overall well-being for at least two hours following treatment.
Recovery & Continued Care
Once you're medically cleared, you'll return home with your designated driver. We'll continue to monitor your progress throughout treatment and make recommendations based on your individual response and goals.
What Does Spravato® Cost?
The cost of Spravato® varies depending on your insurance coverage, deductible, and treatment plan. Before starting treatment, our team will:
Verify your insurance benefits
Obtain any required prior authorizations
Explain your expected out-of-pocket costs
Help determine whether you qualify for manufacturer savings programs
Our goal is to make the process as simple and transparent as possible, so you understand your coverage before beginning treatment.
Have questions about your insurance? Contact our office—we're happy to help verify your benefits.
Taking The First Step Towards Healing-
Seeking help can feel overwhelming, but you don't have to navigate it alone. At Journey to Wellness, we take the time to understand your story and create a personalized treatment plan. Your consultation is a chance to ask questions, explore your options, and decide what feels right for you—without pressure or obligation.
Wondering if Spravato® Is Right for You?
You don't have to make that decision on your own.
We'll review your symptoms, previous treatments, medical history, and goals before recommending whether Spravato® or another treatment option is the best fit for your individual needs.